Ole-Jakob How
Professor II
Faculty of Biosciences and Aquaculture
2026
Porcine Cardiac Arrest Model Using an Implantable Defibrillator 2026 Journal of Visualized Experiments - Benjamin Storm, Knut Tore Lappegård, Charlotte Ingeborg Björk Ingul, Erik Waage Nielsen, Bent Aksel Nilsen, Anette Nyjordet, Ole-Jakob How, Bjørn Ove Faldaas
2024
A hands-free carotid Doppler can identify spontaneous circulation without interrupting cardiopulmonary resuscitation: an animal study 2024 Intensive Care Medicine Experimental - Bjørn Ove Faldaas, Benjamin Stage Storm, Knut Tore Lappegård, Ole-Jakob How, Bent Aksel Nilsen, Gabriel Hanssen Kiss, Eirik Skogvoll, Erik Waage Nielsen, Hans Torp, Charlotte Ingeborg Björk Ingul
2023
Hands-free continuous carotid Doppler ultrasound for detection of the pulse during cardiac arrest in a porcine model 2023 Resuscitation Plus - Bjørn Ove Faldaas, Erik Waage Nielsen, Benjamin Storm, Knut Tore Lappegård, Ole-Jakob How, Bent Aksel Nilsen, Gabriel Hanssen Kiss, Eirik Skogvoll, Hans Torp, Charlotte Ingeborg Björk Ingul
2021
The β3 adrenergic receptor antagonist L-748,337 attenuates dobutamine-induced cardiac inefficiency while preserving inotropy in anesthetized pigs 2021 Journal of Cardiovascular Pharmacology and Therapeutics - Lars Rødland, Leif Reidar Brenk Rønning, Anders Benjamin Kildal, Ole-Jakob How
2020
The effect of Riociguat on cardiovascular function and efficiency in healthy, juvenile pigs 2020 Physiological Reports - Torvind Næsheim, Ole-Jakob How, Truls Myrmel
2019
Combined therapy with dobutamine and omecamtiv mecarbil in pigs with ischemic acute heart failure is attributed to the effect of dobutamine 2019 Journal of Cardiovascular Pharmacology and Therapeutics - Lars Rødland, Leif Reidar Brenk Rønning, Anders Benjamin Kildal, Truls Myrmel, Ole-Jakob How
2018
Opposite diastolic effects of omecamtiv mecarbil versus dobutamine and ivabradine co-treatment in pigs with acute ischemic heart failure 2018 Physiological Reports - Leif Reidar Brenk Rønning, Jens Petter Bakkehaug, Lars Rødland, Anders Benjamin Kildal, Truls Myrmel, Ole-Jakob How
2017
Propulsion of blood through the right heart circulatory system 2017 Scandinavian Cardiovascular Journal - Torvind Næsheim, Ole-Jakob How, Truls Myrmel
2016
Reversing dobutamine-induced tachycardia using ivabradine increases stroke volume with neutral effect on cardiac energetics in left ventricular post-ischaemia dysfunction 2016 Acta Physiologica - Jens Petter Bakkehaug, Torvind Næsheim, Erik Torgersen Engstad, Anders Benjamin Kildal, Truls Myrmel, Ole-Jakob How
2015
Myosin activator omecamtiv mecarbil increases myocardial oxygen consumption and impairs cardiac efficiency mediated by resting myosin ATPase activity 2015 Circulation: Heart Failure - Jens Petter Bakkehaug, Anders Benjamin Kildal, Erik Torgersen Engstad, Neoma Tove Boardman, Torvind Næsheim, Leif R. Rønning, Ellen Aasum, Terje Larsen, Truls Myrmel, Ole-Jakob How
Prolonged observation time reveals temporal fluctuations in the sublingual microcirculation in pigs given arginine vasopressin 2015 Journal of applied physiology - Anders Benjamin Kildal, Thor Allan Stenberg, Espen Sanden, Truls Myrmel, Ole-Jakob How
2014
Effect of transverse aortic constriction on cardiac structure, function and gene expression in pregnant rats 2014 PLOS ONE - Nils Thomas Songstad, David Johansen, Ole-Jakob How, Per Ivar Kaaresen, Kirsti Ytrehus, Ganesh Acharya
The acute phase of experimental cardiogenic shock is counteracted by microcirculatory and mitochondrial adaptations 2014 PLOS ONE - Thor Allan Stenberg, Anders Benjamin Kildal, Espen Sanden, Ole-Jakob How, Martin Hagve, Kirsti Ytrehus, Terje Larsen, Truls Myrmel
2012
Cardiomyocyte-restricted inhibition of G protein-coupled receptor kinase-3 attenuates cardiac dysfunction after chronic pressure overload 2012 American Journal of Physiology. Heart and Circulatory Physiology - Thomas Gero von Lueder, Jørgen A. Gravning, Ole-Jakob How, Leif Erik Vinge, Muhammad Shakil Ahmed, Kurt Allen Krobert, Finn Olav Levy, Terje Larsen, Otto A. Smiseth, Ellen Aasum, Håvard Attramadal
Changes in cardiovascular effects of dopamine in response to graded hypothermia in vivo 2012 Critical Care Medicine - Ole Magnus Filseth, Ole-Jakob How, Timofey Kondratyev, Tor Magne Gamst, Georg Sager, Torkjel Tveita
Adrenomedullin-epinephrine cotreatment enhances cardiac output and left ventricular function by energetically neutral mechanisms 2012 American Journal of Physiology. Heart and Circulatory Physiology - Thor Allan Stenberg, Anders Benjamin Kildal, Ole-Jakob How, Truls Myrmel
2011
Inflammation and reduced endothelial function in the course of severe acute heart failure 2011 Translational Research: The Journal of Laboratory and Clinical Medicine - Stig eggen Hermansen, Trine Kalstad, Ole-Jakob How, truls Myrmel
Effect of Angiotensin II on the Left Ventricular Function in a Near-Term Fetal Sheep with Metabolic Acidemia 2011 Journal of Pregnancy - Ganesh Acharya, James Huhta, Mervi Haapsamo, Ole-Jakob How, Tiina Erkinaro, J Räsänen
2010
Dobutamine-norepinephrine, but not vasopressin, restores the ventriculoarterial matching in experimental cardiogenic shock 2010 Translational Research: The Journal of Laboratory and Clinical Medicine - Ole-Jakob How, Assami Rösner, Anders Benjamin Kildal, Thor Allan Stenberg, Petter Fosse Gjessing, Stig Eggen Hermansen, Truls Myrmel
Post-hypothermic cardiac left ventricular systolic dysfunction after rewarming in an intact pig model 2010 Critical Care - Ole Magnus Filseth, Ole-Jakob How, Timofei Kondratiev, Tor Magne Gamst, Torkjel Tveita
High Resolution Speckle Tracking Dobutamine Stress Echocardiography Reveals Heterogeneous Responses in Different Myocardial Layers: Implication for Viability Assessments 2010 Journal of the American Society of Echocardiography - Assami Rösner, Ole-Jakob How, Erling Johan Aarsæther, Thor Allan Stenberg, Thomas Vennø Andreasen, Timofei Kondratiev, Terje Larsen, Truls Myrmel
Oxygen-Wasting Effect of Inotropy Is There a Need for a New Evaluation? An Experimental Large-Animal Study Using Dobutamine and Levosimendan 2010 Circulation: Heart Failure - Stig Müller, Ole-Jakob How, Øyvind Jakobsen, Stig Eggen Hermansen, Assami Røsner, Thor Allan Stenberg, Truls Myrmel
2009
Left ventricular size determines tissue Doppler-derived longitudinal strain and strain rate 2009 European Heart Journal-Cardiovascular Imaging - A Rösner, B Bijnens, Magna Hansen, Ole-Jakob How, Erling Johan Aarsæther, Stig Müller, GR Sutherland, truls Myrmel
2008
Cardiac-Restricted Expression of The Carboxyl-Terminal Fragment of GRK3 Uncovers Distinct Functions of GRK3 in Regulation of Cardiac Contractility and Growth – GRK3 controls cardiac a1-adrenergic receptor responsiveness 2008 Journal of Biological Chemistry - Leif Erik Vinge, Thomas Von Lueder, Ellen Aasum, Eirik Qvigstad, Jørgen A. Gravning, Ole-Jakob How, Thor Edvardsen, Reidar Bjørnerheim, M. Shakil Ahmed, Birthe W. Mikkelsen, Erik Øie, Toril Attramadal, Tor Skomedal, Otto A Smiseth, Walter J. Koch, Terje Larsen, Håvard Attramadal
Utilization and outcome of coronary revascularization and valve procedures in acute heart failure – an evaluation based on the classification from the European Society of Cardiology 2008 Interactive Cardiovascular and Thoracic Surgery - Stig eggen Hermansen, Magna Hansen, Marius Håke Roaldsen, Stig Müller, Ole-Jakob How, truls Myrmel
Left ventricular size determines tissue Doppler-derived longitudinal strain and strain rate 2008 European Heart Journal-Cardiovascular Imaging - Assami Røsner, B Bijnens, Magna Hansen, Ole-Jakob How, Erling Johan Aarsæther, Stig Müller, GR Sutherland, truls Myrmel
How many acute heart failure patients need a ventricular assist device? 2008 Scandinavian Cardiovascular Journal - Stig eggen Hermansen, truls Myrmel, Magna Hansen, Ole-Jakob How, Stig Müller, Marius Håke Roaldsen
Vasopressin impairs brain, heart and kidney perfusion: an experimental study in pigs after transient myocardial ischemia 2008 Critical Care - Stig Müller, Ole-Jakob How, Stig eggen Hermansen, Thor Allan Stenberg, Georg Sager, truls Myrmel
Fenofibrate modulates cardiac and hepatic metabolism and increases ischemic tolerance in diet-induced obese mice 2008 Journal of Molecular and Cellular Cardiology - Ellen Aasum, Ahmed Murtaz Khalid, Oddrun Anita Gudbrandsen, Ole-Jakob How, Rolf Berge, Terje Larsen
2007
Rosiglitazone treatment improves cardiac efficiency in hearts from diabetic mice 2007 Archives of Physiology and Biochemistry - Ole-Jakob How, Terje Larsen, Anne Dragøy Hafstad, Ahmed Murtaz Khalid, Eivind S. P. Myhre, AJ Myrray, Neoma Boardman, M Cole, Kieran Clarke, David Lester Severson, Ellen Aasum
Glucose and insulin improve cardiac efficiency and postischemic functional recovery in perfused hearts from type 2 diabetic (db/db) mice 2007 American Journal of Physiology. Endocrinology and Metabolism - Anne Dragøy Hafstad, Ahmed Murtaz Khalid, Ole-Jakob How, Terje Larsen, Ellen Aasum
2006
Increased myocardial oxygen consumption reduces cardiac efficiency in diabetic mice 2006 Diabetes - Ole-Jakob How, Ellen Aasum, David Lester Severson, A Chan, M Fadiel Essop, Terje Larsen
Oxygen wastage in the diabetic heart. Ventricular energetics in the isolated mouse heart using PVA-MVO2 technology 2006 - Ole-Jacob How, Terje Larsen
2005
Influence of substrate supply on cardiac efficiency, as measured by pressure-volume analysis in ex vivo mouse hearts 2005 American Journal of Physiology. Heart and Circulatory Physiology - Ole-Jacob How, Ellen Aasum, S Kunnathu, David Lester Severson, Eivind S.p. Myhre, Terje Larsen
2023
Real Time Feedback of Chest Compressions by Hands-Free Carotid Doppler in a Porcine Model 2023 Circulation - Bjørn Ove Faldaas, Erik Waage Nielsen, Benjamin Stage Storm, Knut Tore Lappegård, Ole-Jakob How, bent aksel nielsen, Gabriel Hanssen Kiss, Eirik Skogvoll, Hans Torp, Charlotte Ingeborg Björk Ingul
2022
Mitochondria bioenergetics; diving vs non-diving mammals 2022 EUROPHYSIOLOGY 2022 - Sandra Núῆez-Egido, Samuel Jakob Geiseler, Lars P. Folkow, Ole-Jakob How
RescueDoppler: Non-invasive Handsfree Carotid Doppler Ultrasound For Continuous Hemodynamic-guided Resuscitation 2022 Circulation - Bjørn Ove Faldaas, Erik Waage Nielsen, Benjamin Stage Storm, Knut Tore Lappegård, Ole-Jakob How, Bent Aksel Nilsen, Gabriel Hanssen Kiss, Eirik Skogvoll, Hans Torp, Charlotte Ingeborg Björk Ingul
2020
Abstract 301: RescueDoppler: Non-invasive Handsfree Carotid Doppler Ultrasound For Continuous Hemodynamic-guided Resuscitation 2020 Resuscitation Science Symposium - Bjørn Ove Faldaas, Erik Waage Nielsen, Benjamin Stage Storm, Knut Tore Lappegård, Ole-Jakob How, Bent Aksel Nilsen, Gabriel Hanssen Kiss, Eirik Skogvoll, Hans Torp, Charlotte Ingeborg Björk Ingul
2015
Response to Letter Regarding Article, "Myosin Activator Omecamtiv Mecarbil Increases Myocardial Oxygen Consumption and Impairs Cardiac Efficiency Mediated by Resting Myosin ATPase Activity" 2015 Circulation: Heart Failure - Jens Petter Bakkehaug, Anders Benjamin Kildal, Erik Torgersen Engstad, Neoma Tove Boardman, Torvind Næsheim, Leif R. Rønning, Ellen Aasum, Terje Larsen, Truls Myrmel, Ole-Jakob How
2013
Elevated preload is critical for synchronization of myocardial lengthening (e) and mitral inflow (E) in acute ischemic acute heart failure 2013 The FASEB Journal - Ole-Jakob How, Torvind Næsheim, Jens Petter Bakkehaug, Timofey Kondratyev, Espen W. Remme, Truls Myrmel
2012
Effect of chronic pressure load on heart structure and function in pregnant rats 2012 European Congress of Periantal Medicine - Nils Thomas Songstad, David Johansen, Ole-Jakob How, Kirsti Ytrehus, Ganesh Acharya
2011
Effect of angiotensin II on the left ventricular function in fetal sheep with metabolic acidemia 2011 American Journal of Obstetrics and Gynecology - James Huhta, Juha Rasanen, Mervi Haapsamo, Tiina Erkinaro, Ganesh Acharya, Ole-Jakob How
2010
CARDIAC FUNCTION DURING SEVERE IMMERSION HYPOTHERMIA AND REWARMING IN PIGS 2010 Intensive Care Medicine - Ole magnus Filseth, Ole-Jakob How, Timofei Kondratiev, Tor Magne Gamst, Torkjel Tveita
DOPAMINE INFUSIONS IN NORMOTHERMIA, SEVERE HYPOTHERMIA AND DURING REWARMING: PHARMACOKINETICS AND CARDIOVASCULAR FUNCTION IN A PIG MODEL OF SURFACE COOLING AND REWARMING 2010 Intensive Care Medicine - OM Filseth, Ole-Jakob How, Timofei Kondratiev, Tor Magne Gamst, Georg Sager, Torkjel Tveita
2009
Circulatory assistance in acute heart failure - where do we go from here? 2009 Scandinavian Cardiovascular Journal - Stig eggen Hermansen, T Næsheim, Ole-Jakob How, truls Myrmel
2007
Inhibition of G protein-coupled receptor kinase-3 (GRK3) rescues cardiac dysfunction after pressure overload 2007 ESC Congress - J Gravning, Thomas Von Lueder, T Edvardsen, Leif Erik Vinge, Ole-Jakob How, Ellen Aasum, MS Ahmed, Otto A Smiseth, Håvard Attramadal
Levosimendan improves mechanical efficiency in stunned pig hearts 2007 European Journal of Heart Failure - Stig Müller, O Jakobsen, Ole-Jakob How, truls Myrmel
Glucose and insulin improve energy metabolism, efficiency and ischemic tolerance in hearts from type 2 diabetic mice 2007 Diabeteskonferansen - Anne Dragøy Hafstad, Ahmed Murtaz Khalid, Ole-Jakob How, Terje Larsen, Ellen Aasum
In vivo administration of tetradecylthioacetic acid (TTA) in mice causes cardiac inefficiency and reduced post-ischemic ventricular function 2007 XIX World congress of the ISHR - Anne Dragøy Hafstad, Ahmed Murtaz Khalid, Ole-Jakob How, Rolf Berge, Terje Larsen, Ellen Aasum
Work-independent assessment of efficiency in ex vivo working rodent hearts within the PVA-MVO2 framework 2007 Acta Physiologica - Ole-Jakob How, Ellen Aasum, Terje Larsen
In vivo administration of tetradecylthioacetic acid (TTA) in mice causes cardiac inefficiency and reduced post-ischemic ventricular function 2007 Journal of Molecular and Cellular Cardiology - Anne Dragøy Hafstad, Ahmed Murtaz Khalid, Ole-Jakob How, Rolf Berge, Terje Larsen, Ellen Aasum
Inhibition of G protein-coupled receptor kinase-3 (GRK3) rescues cardiac dysfunction after pressure overload 2007 European Heart Journal - J Gravning, Thomas Von Lueder, T Edvardsen, Leif Erik Vinge, Ole-Jakob How, Ellen Aasum, MS Ahmed, Terje Larsen, Otto A Smiseth, Håvard Attramadal
2006
Chronic and acute metabolic interventions improve cardiac metabolism and enhances cardiac efficiency and ischemic tolerance in type 2 diabetes 2006 2006 Scientific Session - Ellen Aasum, Anne Dragøy Hafstad, Ole-Jakob How, Ahmed Murtaz Khalid, david lester Severson, Terje Larsen
Elevated glucose and insulin improve cardiac efficiency and post-ischemic functional recovery in perfused hearts from type 2 diabetic (db/db) mice 2006 4th Annual Meeting of the Society for Heart and Vascular Metabolism - Anne Dragøy Hafstad, Ahmed Murtaz Khalid, Ole-Jakob How, Terje Larsen, Ellen Aasum
Rosiglitazone treatment improves cardiac efficiency and post-ischemic functional recovery in hearts from diabetic mice 2006 Cardiovascular Drugs and Therapy - Ole-Jakob How, Terje Larsen, Anne Dragøy Hafstad, Ahmed Murtaz Khalid, Eivind S. P. Myhre, david lester Severson, Ellen Aasum
Elevated glucose and insulin improves cardiac efficiency and post-ischemic functional recovery in perfused hearts from type 2 diabetic (db/db) mice 2006 Cardiovascular Drugs and Therapy - Anne Dragøy Hafstad, Ahmed Murtaz Khalid, Ole-Jakob How, Terje Larsen, Ellen Aasum
Changing myocardial energy utilization from fat to glucose improves post-ischemic recovery in hearts from type 2 diabetic (db/db) mice 2006 26th Annual Scientific Sessions, European Section - Anne Dragøy Hafstad, Ahmed Murtaz Khalid, Ole-Jakob How, Terje Larsen, Ellen Aasum
Chronic and acute metabolic interventions improve cardiac metabolism and enhances cardiac efficiency and ischemic tolerance in type 2 diabetes 2006 Circulation - Ellen Aasum, Anne Dragøy Hafstad, Ole-Jakob How, Ahmed Murtaz Khalid, david lester Severson, Terje Larsen
Improved cardiac metabolism enhances cardiac efficiency and ischemic tolerance in type 2 diabetes 2006 Circulation - Ellen Aasum, Anne Dragøy Hafstad, Ole-Jakob How, Ahmed Murtaz Khalid, Terje Larsen
Inhibition of G protein-coupled receptor kinase-3 (GRK3) rescues cardiac dysfunction after pressure overload 2006 Circulation - JA Graving, T Von Leuder, T Edvardsen, Ole-Jakob How, Ellen Aasum, MS Ahmed, Leif Erik Vinge, BV Mikkelsen, Terje Larsen, Otto A Smiseth, Håvard Attramadal
The type 2 diabetic heart is not an insulin resistant organ 2006 Exercise in Medicine - Anne Dragøy Hafstad, Ahmed Murtaz Khalid, Ole-Jakob How, Terje Larsen, Ellen Aasum
Changing myocardial energy utilization from fat to glucose improves post-ischemic recovery in hearts from type 2 diabetic (db/db) mice 2006 Journal of Molecular and Cellular Cardiology - Anne Dragøy Hafstad, Ahmed Murtaz Khalid, Ole-Jakob How, Terje Larsen, Ellen Aasum
Rosiglitazone improves cardiac efficiency and recovery of ventricular function following ischemia in hearts from type 2 diabetic mice 2006 Heart Failure 2006 - Ole-Jakob How, Terje Larsen, Anne Dragøy Hafstad, Ahmed Murtaz Khalid, Eivind S. P. Myhre, david lester Severson, Ellen Aasum
Inhibition of G Protein-Coupled Receptor Kinase-3 (GRK3) rescues Cardiac dysfunction after pressure overload 2006 2006 Scientific Session - JA Graving, Thomas Von Lueder, T Edvardsen, Ole-Jakob How, Ellen Aasum, MS Ahmed, LE Vinge, BV Mikkelsen, Terje Larsen, Otto A Smiseth, Håvard Attramadal
Rosiglitazone treatment improves cardiac efficiency and post-ischemic functional recovery in hearts from diabetic mice 2006 4th. Annual meeting - Ole-Jakob How, Terje Larsen, Anne Dragøy Hafstad, Ahmed Murtaz Khalid, Eivind S. P. Myhre, david lester Severson, Ellen Aasum
2005
Cardiac Efficiency is Reduced in Hearts from Diabetic Mice 2005 3rd. annual meeting of the Society for Heart and Vascular Metabolism - Ole-Jacob How, Ellen Aasum, David Lester Severson, A Chan, M Fadiel Essop, Terje Larsen
Cardiac-specific inhibition of G protein-couplet receptor kinase-3 transgenic mice causes preload-intolerant, hyperkinetic myocardium and hypertensive phenotype 2005 Hjerteforum - Thomas Von Lueder, Leif Erik Vinge, Ellen Aasum, Ole-Jacob How, Reidar Bjørnerheim, Eirik Qvigstad, Terje Larsen, Otto A Smiseth, Håvard Attramadal
Altered pressure-volume relationships in hearts from diabetic mice: a possible mechanism of diabetic cardiomyopathy? 2005 European Section of International Society for Heart Research - Ole-Jacob How, Ellen Aasum, David Lester Severson, Terje Larsen
Altered pressure-volume relationships in hearts from diabetic mice: a possible mechanism of diabetic cardiomyopathy? 2005 Journal of Molecular and Cellular Cardiology - Ole-Jacob How, Ellen Aasum, David Lester Severson, Terje Larsen
Cardiac-specific inhibition of G protein-couplet receptor kinase-3 transgenic mice causes preload-intolerant, hyperkinetic myocardium and hypertensive phenotype 2005 Kardiologisk vintermøte - Thomas Von Lueder, Leif Erik Vinge, Ellen Aasum, Ole-Jacob How, Reidar Bjørnerheim, Eirik Qvigstad, Terje Larsen, Otto A Smiseth, Håvard Attramadal
2004
Different effects of PPAR ligands on cardiac metabolism in mice fed high fat diet 2004 Second annual meeting of the Society for Heart and Vascular Metabolism - Ellen Aasum, Ahmed Murtaz Khalid, Oddrun Anita Gudbrandsen, Ole-Jacob How, Rolf Berge, Terje Larsen
Influence of substrate supply on cardiac efficiency, as measured by pressure-volume analysis in ex vivo mouse hearts 2004 ISHR - Ole-Jacob How, Ellen Aasum, Stanley Kunnathu, David Lester Severson, Terje Larsen
Influence of substrate supply on cardiac efficiency, by pressure-volume analysis in ex vivo mouse hearts 2004 Journal of Molecular and Cellular Cardiology - Ole-Jacob How, Ellen Aasum, S Kunnathu, David Lester Severson, Terje Larsen