Terhi Hannele Kärpänen

A T cell receptor targeting a recurrent driver mutation in FLT3 mediates elimination of primary human acute myeloid leukemia in vivo 2023 Nature Cancer - Eirini Chrysovalantou Giannakopoulou, Madeleine Lehander, Stina Virding Culleton, Weiwen Yang, Yingqian Li, Terhi Hannele Kärpänen, Tetsuichi Yoshizato, Even Holth Rustad, Morten Milek Nielsen, Ravi Chand Bollineni, Trung Tran, Marina Delic-Sarac, Thea Johanne Gjerdingen, Dimitrios Karolos Douvlataniotis, Maarja Laos, Amy Hillen, Muhammad Ali, Stefania Mazzi, Desmond Wai Loon Chin, Adi Mehta, Jeppe Sejerø Holm, Amalie Kai Bentzen, Marie Bill, Marieke Griffioen, Tobias Gedde-Dahl, Sören Lehmann, Sten Eirik W. Jacobsen, Petter S. Woll, Johanna Olweus

An evolutionarily conserved role for Polydom/Svep1 during lymphatic vessel formation 2017 Circulation Research - Terhi Hannele Kärpänen, Yvonne Padberg, Serge A. Van De Pavert, Cathrin Dierkes, Nanami Morooka, Josi Peterson-Maduro, Glenn Van De Hoek, Max Adrian, Naoki Mochizuki, Kiyotoshi Sekiguchi, Friedemann Kiefer, Dörte Schulte, Stefan Schulte-Merker

The Potential of Donor T-Cell Repertoires in Neoantigen-Targeted Cancer Immunotherapy 2017 Frontiers in Immunology - Terhi Hannele Kärpänen, Johanna Olweus

Efficient activation of the lymphangiogenic growth factor VEGF-C requires the C-terminal domain of VEGF-C and the N-terminal domain of CCBE1 2017 Scientific Reports - Sawan Kumar Jha, Khushbu Rauniyar, Terhi Hannele Kärpänen, Veli-Matti Leppanen, Pascal Brouillard, Mikka Vikkula, Kari Alitalo, Michael Jeltsch

T-cell receptor gene therapy - ready to go viral? 2015 Molecular Oncology - Terhi Hannele Kärpänen, Johanna Olweus

Ccbe1 regulates Vegfc-mediated induction of Vegfr3 signaling during embryonic lymphangiogenesis 2014 Development - Ludovic Le Guen, Terhi Hannele Kärpänen, Dörte Schulte, Nicole C Harris, Katarzyna Koltowska, Guy Roukens, Neil I Power, Andreas van Impel, Steven A Stacker, Marc G Achen, Stefan Schulte-Merker, Benjamin M Hogan

CCBE1 Enhances Lymphangiogenesis via A Disintegrin and Metalloprotease With Thrombospondin Motifs-3–Mediated Vascular Endothelial Growth Factor-C Activation 2014 Circulation - Michael Jeltsch, Sawan Kumar Jha, Denis Dvorogov, Andrey Anisimov, Veli-Matti Leppanen, Tanja Holopainen, Riikka Kivelä, Sagrario Ortega, Terhi Hannele Kärpänen, Kari Alitalo

The zebrafish common cardinal veins develop by a novel mechanism: lumen ensheathment 2013 Development - Christian S M Helker, Annika Schuermann, Terhi Hannele Kärpänen, Dagmar Zeuschner, Heinz-Georg Belting, Markus Affolter, Stefan Schulte-Merker, Wiebke Herzog

CCBE1 Is Essential for Mammalian Lymphatic Vascular Development and Enhances the Lymphangiogenic Effect of Vascular Endothelial Growth Factor-C In Vivo 2011 Circulation Research - Frank L Bos, Maresa Caunt, Josi Peterson-Maduro, Lara Planaz-Paz, Joe Kowalski, Terhi Hannele Kärpänen, Andreas van Impel, Raymond Tong, James A Ernst, Jeroen Korving, Johan H van Es, Eckhard Lammert, Henricus J Duckers, Stefan Schulte-Merker

Zebrafish Provides a Novel Model for Lymphatic Vascular Research 2011 Methods in Cell Biology - Terhi Hannele Kärpänen, Stefan Schulte-Merker

Notch restricts lymphatic vessel sprouting induced by vascular endothelial growth factor 2011 Blood - Wei Zheng, Tuomas Tammela, Masahiro Yamamoto, Andrey Anisimov, Tanja Holopainen, Seppo Kaijalainen, Terhi Hannele Kärpänen, Kaisa Lehti, Seppo Ylä-Herttuala, Kari Alitalo

miR-31 Functions as a Negative Regulator of Lymphatic Vascular Lineage-Specific Differentiation In Vitro and Vascular Development In Vivo 2010 Molecular and Cellular Biology - Deena M Leslie Pedrioli, Terhi Hannele Kärpänen, Vasilios Dabouras, Giorgia Jurisic, Glenn Van De Hoek, Jay W. Shin, Daniela Marino, Roland E. Kälin, Sebastian Leidel, Paolo Cinelli, Stefan Schulte-Merker, Andre W Brandli, Michael Detmar

Targeting Lymphatic Vessel Activation and CCL21 Production by Vascular Endothelial Growth Factor Receptor-3 Inhibition Has Novel Immunomodulatory and Antiarteriosclerotic Effects in Cardiac Allografts 2010 Circulation - Antti I Nykänen, Henrik Sandelin, Reiner Krebs, Mikko A I Keränen, Raimo Tuuminen, Terhi Hannele Kärpänen, Yan Wu, Bronislaw Pytowski, Petri K Koskinen, Seppo Ylä-Herttuala, Kari Alitalo, Karl B. Lemström

Overexpression of Vascular Endothelial Growth Factor-B in Mouse Heart Alters Cardiac Lipid Metabolism and Induces Myocardial Hypertrophy 2008 Circulation Research - Terhi Hannele Kärpänen, Maija Bry, Hanna M. Ollila, Tuulikki Seppänen-Laakso, Erkki Liimatta, Hanna Leskinen, Riikka Kivelä, Teemu Helkamaa, Mari Merentie, Michael Jeltsch, Karri Paavonen, Leif C Andersson, Eero Mervaala, Ilmo E Hassinen, Seppo Ylä-Herttuala, Matej Orešič, Kari Alitalo

Molecular Biology and Pathology of Lymphangiogenesis 2008 Annual Review of Pathology - Terhi Hannele Kärpänen, Kari Alitalo

VEGF-D: a modifier of embryonic lymphangiogenesis 2008 Blood - Terhi Hannele Kärpänen, Kari Alitalo

Enhanced Capillary Formation Stimulated by a Chimeric Vascular Endothelial Growth Factor/Vascular Endothelial Growth Factor-C Silk Domain Fusion Protein 2007 Circulation Research - Salla Keskitalo, Tuomas Tammela, Johannes Lyytikka, Terhi Hannele Kärpänen, Michael Jeltsch, Johanna Markkanen, Seppo Ylä-Herttuala, Kari Alitalo

Lymphatic vessels in health and disease: Role of the VEGF-C/VEGFR-3 pathway and the transcription factor FOXC2 2006 - Kari Alitalo, Terhi Hannele Kärpänen

Vascular Endothelial Growth Factor (VEGF)/VEGF-C Mosaic Molecules Reveal Specificity Determinants and Feature Novel Receptor Binding Patterns 2006 Journal of Biological Chemistry - Michael Jeltsch, Terhi Hannele Kärpänen, Tomas Strandin, Kukka Aho, Hilkka Lankinen, Kari Alitalo

Functional interaction of VEGF-C and VEGF-D with neuropilin receptors 2006 The FASEB Journal - Terhi Hannele Kärpänen, Caroline A. Heckman, Salla Keskitalo, Michael Jeltsch, Hanna M. Ollila, Gera Neufeld, Luca Tamagnone, Kari Alitalo

Regulation of lymphangiogenesis—From cell fate determination to vessel remodeling 2006 Experimental Cell Research - Terhi Hannele Kärpänen, Taija Mäkinen

Lymphangiogenic Growth Factor Responsiveness Is Modulated by Postnatal Lymphatic Vessel Maturation 2006 American Journal of Pathology - Terhi Hannele Kärpänen, Maria Wirzenius, Taija Mäkinen, Tanja Veikkola, Hidde J Haisma, Marc G Achen, Steven A Stacker, Bronislaw Pytowski, Seppo Ylä-Herttuala, Kari Alitalo

Periadventitial angiopoietin-1 gene transfer induces angiogenesis in rabbit carotid arteries 2005 Gene Therapy - S. Bhardwaj, H. Roy, Terhi Hannele Kärpänen, Y Hi, S Jauhiainen, M Hedman, Kari Alitalo, Seppo Ylä-Herttuala

Defective valves and abnormal mural cell recruitment underlie lymphatic vascular failure in lymphedema distichiasis 2004 Nature Medicine - Tatiana V Petrova, Terhi Hannele Kärpänen, Camilla Norrmen, Russell Mellor, Tomoki Tamakoshi, David Finegold, Robert Ferrell, Dontscho Kerjaschki, Peter Mortimer, Seppo Ylä-Herttuala, Naoyuki Miura, Kari Alitalo

PDGF-D induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis 2004 Blood - Marko Uutela, Maria Wirzenius, Karri Paavonen, Iiro Rajantie, Yulong He, Terhi Hannele Kärpänen, Marja Lohela, Helge Wiig, Petri Salven, Katri Pajusola, Ulf Eriksson, Kari Alitalo

Role of lymphangiogenic factors in tumor metastasis 2004 Biochimica et Biophysica Acta. CR. Reviews on Cancer - Yulong He, Terhi Hannele Kärpänen, Kari Alitalo

Antitumor activity of a homing peptide that targets tumor lymphatics and tumor cells 2004 PNAS - Pirjo Laakkonen, Maria E Åkerman, Hector Biliran, Meng Yang, Fernando Ferrer, Terhi Hannele Kärpänen, Robert M Hoffman, Erkki Ruoslahti

VEGF-C induced lymphangiogenesis is associated with lymph node metastasis in orthotopic MCF-7 tumors 2002 International Journal of Cancer - Mirjami MT Mattila, Johanna K Ruohola, Terhi Hannele Kärpänen, David G Jackson, Kari Alitalo, Pirkko L Härkönen

Vascular Endothelial Growth Factor Ligands and Receptors That Regulate Human Cytotrophoblast Survival Are Dysregulated in Severe Preeclampsia and Hemolysis, Elevated Liver Enzymes, and Low Platelets Syndrome 2002 American Journal of Pathology - Yan Zhou, Michael McMaster, Kirstin Woo, Mary Janatpour, Jean Perry, Terhi Hannele Kärpänen, Kari Alitalo, Caroline Damsky, Susan J. Fisher

Suppression of Tumor Lymphangiogenesis and Lymph Node Metastasis by Blocking Vascular Endothelial Growth Factor Receptor 3 Signaling 2002 Journal of the National Cancer Institute - Yulong He, Ken-ichi Kozaki, Terhi Hannele Kärpänen, Katsumi Kochikawa, Seppo Ylä-Herttuala, Takashi Takahashi, Kari Alitalo

Signalling via vascular endothelial growth factor receptor-3 is sufficient for lymphangiogenesis in transgenic mice 2001 EMBO Journal - Tanja Veikkola, Lotta Jussila, Taija Mäkinen, Terhi Hannele Kärpänen, Michael Jeltsch, Tatiana V Petrova, Hajime Kubo, Gavin Thurston, Donald M. McDonald, Marc G Achen, Steven A Stacker, Kari Alitalo

Lymphatic Vessels as Targets of Tumor Therapy? 2001 Journal of Experimental Medicine (JEM) - Terhi Hannele Kärpänen, Kari Alitalo

Adenoviral Expression of Vascular Endothelial Growth Factor-C Induces Lymphangiogenesis in the Skin 2001 Circulation Research - Berndt Enholm, Terhi Hannele Kärpänen, Michael Jeltsch, Hajime Kubo, Frej Stenback, Remko Prevo, David G Jackson, Seppo Ylä-Herttuala, Kari Alitalo

The Drosophila VEGF receptor homolog is expressed in hemocytes 2001 Mechanisms of Development - Tapio I Heino, Terhi Hannele Kärpänen, Gudrun Wahlström, Marianne Pulkkinen, Ulf Eriksson, Kari Alitalo, Christophe Roos

Inhibition of lymphangiogenesis with resulting lymphedema in transgenic mice expressing soluble VEGF receptor-3 2001 Nature Medicine - Taija Mäkinen, Lotta Jussila, Tanja Veikkola, Terhi Hannele Kärpänen, Mikko I Kettunen, Kalevi J Pulkkanen, Risto Kauppinen, David G Jackson, Hajime Kubo, Shin-Ichi Nishikawa, Seppo Ylä-Herttuala, Kari Alitalo

Isolated lymphatic endothelial cells transduce growth, survival and migratory signals via the VEGF-C/D receptor VEGFR-3 2001 EMBO Journal - Taija Mäkinen, Tanja Veikkola, Satu Mustjoki, Terhi Hannele Kärpänen, Bruno Catimel, Edouard C. Nice, Lyn Wise, Andrew Mercer, Heinrich Kowalski, Dontscho Kerjaschki, Steven A Stacker, Marc G Achen, Kari Alitalo

Vascular Endothelial Growth Factor C Promotes Tumor Lymphangiogenesis and Intralymphatic Tumor Growth 2001 Cancer Research - Terhi Hannele Kärpänen, Mikala Egeblad, Marika J. Karkkainen, Hajime Kubo, Seppo Ylä-Herttuala, Marja Jäättelä, Kari Alitalo

Mechanisms of angiogenesis and their use in the inhibition of tumor growth and metastasis 2000 Oncogene - Anne Saaristo, Terhi Hannele Kärpänen, Kari Alitalo

Biosynthesis of Vascular Endothelial Growth Factor-D Involves Proteolytic Processing Which Generates Non-covalent Homodimers 1999 Journal of Biological Chemistry - Steven A Stacker, Kaye Stenvers, Carol Caesar, Angela Vitali, Teresa Domagala, Edouard C. Nice, Sally Roufail, Richard J. Simpson, Robert Moritz, Terhi Hannele Kärpänen, Kari Alitalo, Marc G Achen

Differential Binding of Vascular Endothelial Growth Factor B Splice and Proteolytic Isoforms to Neuropilin-1 1999 Journal of Biological Chemistry - Taija Mäkinen, Birgitta Olofsson, Terhi Hannele Kärpänen, Ulf Hellman, Shay Soker, Michael Klagsbrun, Ulf Eriksson, Kari Alitalo